歷年論文發表

Completed Publication List (* corresponding author)

  1. Chang YW, Hsiao HW, Chen JP, Tzeng SF, Tsai CH, Wu CY, Hsieh HH, Carmona SJ, Andreatta M, Di Conza G, Su MT, Koni PA, Ho PC, Chen HK,Yang MH* . A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8+ T cells. Cell Rep Med. 2023 Aug 15;4(8):101154. 
  2. Chung CH, Lin CY, Chen CY, Hsueh CW, Chang YW, Wang CC, Chu PY, Tai SK, Yang MH*. Ferroptosis signature shapes the immune profiles to enhance the response to immune checkpoint inhibitors in head and neck cancer. Adv Sci (Weinh). 2023 Apr 7;e2204514.
  3. Lee TL, Chen TH, Kuo YJ, Lan HY, Yang MH*, Chu PY*. Tumor-associated tissue eosinophilia promotes angiogenesis and metastasis in head and neck squamous cell carcinoma. Neoplasia 2023; Jan;35:100855.
  4. Chen HY, Hsieh, CH, Lin PH, Chen YT, Hsu DS, Tai SK, Chu PY, Yang MH*. Snail regulated microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance. J Immunother Cancer 2022; 10: e004832.
  5. Chen JY, Chou HH, Lim SC, Huang YJ, Lai KC, Guo CL, Tung CY, Su CT, Wang J, Liu E, Han HF, Yeh PY, Hu CM, Dunn AR, Frank CW, Wu YC*, Yang MH*, Chang YC*. Multiomic characterization and drug testing establish circulating tumor cells as an ex vivo tool for personalized medicine. iScience 2022;25:105081.
  6. Lai CL, Chen TH, Chang PM, Tai SK, Chu PY, Yang MH*. Efficacy of cetuximab-containing regimens in the treatment of recurrent/metastatic head and neck cancer after progression to immune checkpoint inhibitors.J Chin Med Assoc 2022;85:687-692.
  7. Ou DL, Chen CW, Hsu CL, Chung CH, Feng ZR, Lee BS, Cheng AL, Yang MH*, Hsu C*. Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages. J Immunother Cancer 2021; 9:e001657.doi: 10.1136/jitc-2020-001657.
  8. Chen CC, Hsu CC, Chen SL, Lin PH, Chen JP, Pan YR, Huang CE, Chen YJ, Chen YY, Wu YY, Yang MH*. RAS mediates BET inhibitor-endued repression of lymphoma migration and prognosticates a novel proteomics-based subgroup of DLBCL through its negative regulator IQGAP3.Cancers 2021; 13: 5024.
  9. Chou MY, Yang MH*. Interplay of immunometabolism and epithelial–mesenchymal transition in the tumor microenvironment. Int J Mol Sci 2021; 22: 9878.
  10. Chen TH, Chang PM, Yang MH*. Combination of pembrolizumab and lenvatinib is a potential treatment option for heavily pretreated recurrent and metastatic head and neck cancer. J Chin Med Assoc 2021; 84:361-7.
  11. Hung YP, Shao YY, Hsu C, Hsu CH, Lee JM, Yang MH*, Chao Y. The unique characteristic in peripheral immune cells in patients with advanced hepatocellular carcinoma. J Formos Med Assoc 2021; 120: 1581-90.
  12. Hung YP, Shao YY, Lee JM, Hsu C, Hsu CH, Yang MH*, Chao Y*. Potential of circulating immune cells as biomarkers of nivolumab treatment efficacy for advanced hepatocellular carcinoma. J Chin Med Assoc 2021; 84: 144-50.
  13. Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH*. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3 in colorectal cancer. Theranostics 2020; 10: 6095-6112.
  14. Liao TT, Yang MH*. Hybrid Epithelial/Mesenchymal State in Cancer Metastasis: Clinical Significance and Regulatory Mechanisms. Cells 2020;9:623 (review article).
  15. Sun NY, Yang MH*. Metabolic reprogramming and epithelial-mesenchymal plasticity: opportunities and challenges for cancer therapy. Front Oncol 2020 DOI: 10.3389/fonc.2020.00792 (review article).
  16. Chien SH, Liu HM, Chen PM, Ko PS, Lin JS, Chen YJ, Lee LH, Hsiao LT, Chiou TJ, Gau JP, Yang MH, Liu CY. The landscape of BCR-ABL mutations in patients with Philadelphia chromosome-positive leukaemias in the era of second-generation tyrosine kinase inhibitors. Hematol Oncol 2020 Feb 3. doi: 10.1002/hon.2721
  17. Grünwald V, Chirovsky D, Cheung WY, Bertolini F, Ahn MJ, Yang MH, Castro G, Berrocal A, Sjoquist K, Kuyas H, Auclair V, Guillaume X, Joo S, Shah R, Harrington K; GLANCE H&N STUDY Investigators. Global treatment patterns and outcomes among patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results of the GLANCE H&N study. Oral Oncol 2020;102:104526.
  18. Yan X, Cao N, Chen Y, Lan HY, Cha JH, Yang WH, Yang MH*. MT4-MMP promotes invadopodia formation and cell motility in FaDu head and neck cancer cells. Biochem Biophys Res Commun 2020; 522:1009-1014.
  19. Chen TH, Chang PM, Yang MH*. Novel immune-modulating drugs for advanced head and neck cancer. Head Neck 2019;41(Suppl 1):46-56 (review article).
  20. Lai SC, Su YT, Chi CC, Kuo YC, Lee KF, Wu YC, Lan PC, Yang MH, Chang TS, Huang YH. DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation. J Exp Clin Cancer Res 2019; 38: 474.
  21. Lee TL, Chiu PH, Li WY, Yang MH, Wei PY, Chu PY, Wang YF, Tai SK. Nerve-tumour interaction enhances the aggressiveness of oral squamous cell carcinoma. Clin Otolaryngol 2019; 44: 1087-1095.
  22. Lai CH, Tsai WS, Yang MH, Chou TY, Chang YC. A two-dimensional immunomagnetic nano-net for the efficient isolation of circulating tumor cells in whole blood. Nanoscale 2019; 11: 21119-21127.
  23. Lu HJ, Hsieh CC, Yeh CC, Yeh YC, Wu CC, Wang FS, Lai JM, Yang MH, Wang CH, Huang CF, Chang PM. Clinical, pathophysiologic, and genomic analysis of the outcomes of primary head and neck malignancy after pulmonary metastasectomy. Sci Rep 2019; 9: 12913.
  24. Yen CC, Chen SC, Hung GY, Wu PK, Chua WY, Lin YC, Yen CH, Chen YC, Wang JY, Yang MH, Chao Y, Chang MC, Chen WM. Expression profile‑driven discovery of AURKA as a treatment target for liposarcoma. Int J Oncol 2019; 55: 938-948.
  25. Ho WT, Chang JS, Chou SF, Hwang WL, Shih PJ, Chang SW, Yang MH, Jou TS, Wang IJ. Targeting non-muscle myosin II promotes corneal endothelial migration through regulating lamellipodial dynamics. J Mol Med (Berl) 2019; 97: 1345-1357.
  26. Chen MH, Chang SC, Lin PC, Yang SH, Lin CC, Lan YT, Lin HH, Lin CH, Lai JI, Liang WY, Lu ML, Yang MH, Chao Y. Combined microsatellite instability and elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) might be a more promising immune biomarker in colorectal cancer. Oncologist 2019; 24: 1534-1542.
  27. Yen CC, Chen LT, Li CF, Chen SC, Chua WY, Lin YC, Yen CH, Chen YC, Yang MH, Chao Y, Fletcher JA. Identification of phenothiazine as an ETV1‑targeting agent in gastrointestinal stromal tumors using the Connectivity Map. Int J Oncol 2019 ;55: 536-546.
  28. Cheng WC, Liao TT, Lin CC, Yuan LE, Lan HY, Lin HH, Teng HW, Chang HC, Lin CH, Yang CY, Huang SC, Jiang JK, Yang SH, Yang MH*, Hwang WL*. RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer.Int J Cancer 2019;145:2209-2224.
  29. Li CF, Chen JY, Ho YH, Hsu WH, Wu, LC, Lan HY, Hsu DS, Tai SK, Chang YC*, Yang MH*. Snail-induced claudin-11 prompts collective migration for tumor progression. Nat Cell Biol 2019; 21:251-262.
  30. Hwang WL*, Lan HY, Cheng WY, Huang SC, Yang MH*. Tumor stem-Like cells-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer. J Hematol Oncol 2019;12:10.
  31. Lee CC, Lin JC, Hwang WL, Kuo YJ, Chen HK, Tai SK, Lin CC, Yang MH*. Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization Nat Commun 2018; 9: 3763.
  32. Pan YR, Chen CC, Chan YT, Wang SJ, Chien FT, Chen YL, Liu JL, Yang MH*. STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas. Nat Commun 2018 9:3696.
  33. Hsieh CH, Tai SK, Yang MH*. Snail-overexpressing cancer cells promotes M2-like polarization of tumor-associated macrophages by delivering miR-21-abundant exosomes. Neoplasia 2018; 20:775-788.
  34. Chen YQ, Lan HY, Wu YC, Yang WH, Chiou A*, Yang MH*. Epithelial-mesenchymal transition softens head and neck cancer cells to facilitate migration in 3D environments. J Cell Mol Med 2018; 22:3837-3846.
  35. Chen HH, Yu HI, Yang MH, Tarn WY. DDX3 activates CBC-eIF3-mediated translation of uORF-containing oncogenic mRNAs to promote metastasis in HNSCC. Cancer Res 2018; 78: 4512-4523.
  36. Huang KH, Sung IC, Fang WL, Chi CW, Yeh TS, Lee HC, Yin PH, Li AF, Wu CW, Shyr YM, Yang MH*. Correlation between HGF/c-Met and Notch1 signaling pathways in human gastric cancer cells. Oncol Rep 2018; 40: 294-302.
  37. Cheng YJ, Tsai MH, Chiang CJ, Tsai ST, Liu TW, Lou PJ, Liao CT, Lin JC, Chang JT, Tsai MH, Chu PY, Leu YS, Tsai KY, Terng SD, Chien CY, Yang MH, Hao SP, Wang CC, Tsai MH, Chen HHW, Kuo C, Wu YH. Adjuvant radiotherapy after curative surgery for oral cavity squamous cell carcinoma and treatment effect of timing and duration on outcome-A Taiwan Cancer Registry national database analysis. Cancer Med 2018 Jun 14. doi: 10.1002/cam4.1611.
  38. Lin MC, Shueng PW, Chang WK, Mu-Hsin Chang P, Feng HC, Yang MH, Lou PJ. Consensus and clinical recommendations for nutritional intervention for head and neck cancer patients undergoing chemoradiotherapy in Taiwan. Oral Oncol 2018;81:16-21 (review article).
  39. Chang PM, Chen CH, Yeh CC, Lu HJ, Liu TT, Chen MH, Liu CY, Wu ATH, Yang MH, Tai SK, Mochly-Rosen D, Huang CF. Transcriptome analysis and prognosis of ALDH isoforms in human cancer. Sci Rep 2018;8:2713.
  40. Chen SC, Liao TT, Yang MH*. Emerging roles of epithelial-mesenchymal transition in hematological malignancies. J Biomed Sci 2018;25:37 (review article).
  41. Huang KH, Fang WL, Li AF, Liang PH, Wu CW, Shyr YM, Yang MH*. Caspase-3, a key apoptotic protein, as a prognostic marker in gastric cancer after curative surgery.Int J Surg 2018; 52:258-263.
  42. Chen SC, Chang PM, Wang HJ, Tai SK, Chu PY*, Yang MH*. PD-L1 expression is associated with p16INK4A expression in non-oropharyngeal head and neck squamous cell carcinoma.Oncol Lett 2018;1: 2259-2265.
  43. Liang ML, Hsieh TH, Liu YR, Chen YW, Lee YY, Chang FC, Lin SC, Huang MC, Donald Ming-Tak H, Wong TT, Yen Y*, Yang MH*. Significance of cyclin D1 overexpression in progression and radio-resistance of pediatric ependymomas. Oncotarget 2017;9:2527-2542.
  44. Chou YT, Jiang JK, Yang MH, Lu JW, Lin HK, Wang HD, Yuh CH. Identification of a noncanonical function for ribose-5-phosphate isomerase A promotes colorectal cancer formation by stabilizing and activating β-catenin via a novel C-terminal domain. PLoS Biol 2018;16:e2003714.
  45. Hung LT, Huang HI, Wang LW, Yang MH, Chu PY. Oncologic results and quality of life in patients with squamous cell carcinoma of hypopharynx after transoral laser microsurgery. Lasers Surg Med 2018;50:117-124.
  46. Liao TT, Yang MH*. Revisiting epithelial-mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness. Mol Oncol 2017; 11:792-804 (review article).
  47. Hsu DS, Hwang WL, Yuh CH, Chu CH, Ho YH, Chen PB, Lin HS, Lin HK, Wu SP, Lin CY, Hsu WH, Lan HY, Wang HJ, Tai SK, Hung MC, Yang MH*. Lymphotoxin-beta interacts with methylated EGFR to mediate acquired resistance to cetuximab in head and neck cancer. Clin Cancer Res 2017; 23: 4388-4401.
  48. Chang PM, Lu HJ, Wang LW, Tai SK, Chen MH, Chu PY*, Yang MH*. Effectiveness of incorporating cetuximab into docetaxel/cisplatin/fluorouracil induction chemotherapy and chemoradiotherapy for inoperable squamous cell carcinoma of the oral cavity: a phase II study. Head Neck 2017; 39: 1333-42.
  49. Hwang WL, Yang MH*. Numb is involved in the non-random segregation of subcellular vesicles in colorectal cancer stem cells. Cell Cycle 2016; 15: 2697-2703.
  50. Chen SC, Chang PM*, Yang MH*. Cisplatin/UFUR/irinotecan triple combination therapy for recurrent/metastatic head and neck squamous cell carcinoma—a phase I/II clinical study. Oncologist 2016;21: 537-8.
  51. Liang ML, Hsieh TH, Ng KH , Tsai YN, Tsai CF , Chao ME, Liu DJ, Chu SS, Chen W, Liu YR, Liu RS, Lin SC, Ho DM, Wong TT*, Yang MH*, Wang HW. Downregulation of miR-137 and miR-6500-3p promotes cell proliferation in pediatric high-grade gliomas. Oncotarget 2016;7: 19723-37.
  52. Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH*. let-7 modulates chromatin configuration and target gene repression through regulation of the ARID3B complex. Cell Rep 2016;14: 520-533.
  53. Yang WH, Su YH, Hsu WH, Wang CC, Arbiser JL*, Yang MH*. Imipramine blue halts head and neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1 degradation. Oncogene 2016;35:2287-98.
  54. Chou YS, Yang MH*. Epithelial-mesenchymal transition-related factors in solid tumor and hematological malignancy. J Chin Med Assoc 2015;78:438-445 (review article).
  55. Chen CC, Gau JP, You JY, Huang CE, Chen YY, Lo WH, Cheng YH, Tsai PS, Chou HJ, Tseng YT, Lung J*, Yang MH*. Favorable clinical outcome and unique characteristics in association with Twist1 overexpression in de novo acute myeloid leukemia. Blood Cancer J 2015; 5: e339.
  56. Hsu DS, Wang SJ, Tai SK, Chou CH, Hsieh CH, Chiu PH, Chen NJ, Yang MH*. Acetylation of Snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell 2014; 26:534-548.
  57. Huang TZ, Chen YJ*, Chou TY, Chen CY, Li HY, Huang BS, Tsai HW, Lan HY, Chang CH, Twu NF, Yen MS, Wang PH, Chao KC, Lee CC, Yang MH*. Estrogen-induced angiogenesis promotes adenomyosis by activating the Slug-VEGF axis in endometrial epithelial cells. J Cell Mol Med 2014; 18: 1358-1371.
  58. Hwang WL, Jiang JK, Yang SH, Huang TS, Lan HY, Teng HW, Yang CY, Tsai YP, Lin CH, Wang HW*, Yang MH*. MicroRNA-146a directs the symmetrical division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol 2014;16: 268-280.
  59. Chen YW, Kao SY, Wang SJ, Yang MH*. Histone modification patterns correlate with patient outcome in oral squamous cell carcinoma. Cancer 2013; 119:4259-67.
  60. Chang CC, Hsu WH, Wang CC, Chou CH, Kuo MY, Lin BR, Chen ST, Tai SK, Kuo ML, Yang MH*. Connective tissue growth factor activates pluripotency genes and mesenchymal-epithelial transition in head and neck cancer cells. Cancer Res. 2013;73:4147-4157.
  61. Tai SK, Li WY, Yang MH, Chu PY, Wang YF. Perineural Invasion in T1 Oral Squamous Cell Carcinoma Indicates the Need for Aggressive Elective Neck Dissection. Am J Surg Pathol. 2013;37: 1164-1172
  62. Lu HJ, Chen KW, Chen MH, Chu PY, Tai SK, Tzeng CH, Chang PM*, Yang MH*. Serum Albumin is an Important Prognostic Factor for Carotid Blowout Syndrome. Jpn J Clin Oncol. 2013;43:532-539.
  63. Kuo YY, Chu PY, Chang SY, Wang YF, Tsai TL, Yang MH, Wang LW, Tai SK. Treatment selection for tonsillar squamous cell carcinoma. J Chin Med Assoc. 2013;76:211-217.
  64. Huang KH, Wang RF, Yang MH, Wu CW, Fang WL, Li AF, Chi CW, Kao HL. Advanced gastric cancer patients with lymphoid stroma have better survival than those without. J Surg Oncol. 2013;107: 523-528.
  65. Yang WH, Lan HY, Tai SK, Yang MH*. Repression of bone morphogenetic protein 4 by let-7i attenuates mesenchymal migration of head and neck cancer cells. Biochem Biophys Res Commun. 2013;433:24-30.
  66. Chang CC, Yang MH, Lin BR, Chen ST, Pan SH, Hsiao M, Lai TC, Lin SK, Jeng YM, Chu CY, Chen RH, Yang PC, Chin YE, Kuo ML. CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation. Cell Death Differ. 2013;20: 443-455.
  67. Chou CH, Yang NK, Liu TY, Tai SK, Hsu DS, Chen YW, Chen YJ, Chang CC, Tzeng CH, Yang MH*. Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer. Cancer Res. 2013;73:953-966.
  68. Huang KH, Wang RF, Yang MH, Wu CW, Fang WL*, Li AF, Chi CW, Kao HL. Advanced gastric cancer patients with lymphoid stroma have better survival than those without. J Surg Oncol. 2013;107:523-528.
  69. Hung SP, Yang MH, Tseng KF, Lee OK. Hypoxia-induced secretion of TGF-beta 1 in mesenchymal stem cell promotes breast cancer cell progression. Cell Transplant. 2013; 22: 1869-1882.
  70. Chen YW, Chen CY, Chiang SC, Lui MT, Kao SY, Yang MH*. Predictors and impact of microsurgical complications in patients with locally advanced oral squamous cell carcinoma. Cancer Sci. 2012;103:1672-1678.
  71. Chua DT, Yiu HH, Seetalarom K, Ng AW, Kurnianda J, Shotelersuk K, Krishnan G, Hong RL, Yang MH, Wang CH, Sze WK, Ng WT. Phase II trial of capecitabine plus cisplatin as first-line therapy in patients with metastatic nasopharyngeal cancer. Head Neck. 2012;34: 1225-1230.
  72. Huang WY, Lin CC, Jen YM, Lin KT, Yang MH, Chen CM, Chang YN, Sung FC, Kao CH*. Association between adult otitis media and nasopharyngeal cancer: A nationwide population-based cohort study. Radiother Oncol. 2012; 104: 338-342.
  73. Chung CY, Lin SF, Chen PM, Chang MC, Kao WY, Chao TY, Hsiao LT, Yen CC, Yang MH, Hwang WS, Lin TL, Chiou TJ, Chang CS*. Thalidomide for the treatment of myelodysplastic syndrome in Taiwan: results of a phase II trial. Anticancer Res 2012; 32: 3415-3419.
  74. Chen YW, Kao SY, Yang MH*. Analysis of p16(INK4A) expression of oral squamous cell carcinomas in Taiwan: prognostic correlation without relevance to betel quid consumption. J Surg Oncol. 2012; 106: 149-54.
  75. Yu YB, Gau JP, Liu CY, Yang MH, Chiang SC, Hsu HC, Hong YC, Hsiao LT, Liu JH, Chiou TJ, Chen PM, Lee TS, Chou LF, Tzeng CH, Chen TJ*. A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system. Thromb Haemost 2012;108: 225-235.
  76. Tai SK*, Li WY, Yang MH, Chang SY, Chu PY, Tsai TL, Wang YF, Chang PM. Treatment for T1-2 oral squamous cell carcinoma with or without perineural invasion: neck dissection and postoperative adjuvant therapy. Ann Surg Oncol 2012;19:1995-2002.
  77. Yang MH, Lin BR, Chang CH, Chen ST, Lin SK, Kuo MY, Jeng YM, Kuo ML, Chang CC*. Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/FOXP1 signalling. Oncogene. 2012;31: 2401-2411.
  78. Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH*. RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol. 2012;14:366-374.
  79. Li CW, Xia W, Huo L, Lim SO, Wu Y, Hsu JL, Chao CH, Yamaguchi H, Yang NK, Ding Q, Wang Y, Lai YJ, LaBaff AM, Wu TJ, Lin BR, Yang MH, Hortobagyi GN, Hung MC*. Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1. Cancer Res. 2012; 72: 1290-1300.
  80. Chen KW, Liu CJ, Lu HJ, Tzeng CH, Liu JH, Chiou TJ, Yen CC, Wang WS, Chao TC, Teng HW, Chen MH, Liu CY, Chang PM, Yang MH. Evaluation of prognostic factors and the role of chemotherapy in unfavorable carcinoma of unknown primary site: a 10-year cohort study. BMC Res Notes. 2012;5: 70
  81. Lu HJ, Chen KW, Tzeng CH, Liu JH, Chiou TJ, Yen CC, Chao TC, Teng HW, Chen MH, Liu CY, Wang WS, Chang PM, Yang MH. Evaluation of prognosis for carcinoma of unknown origin in elderly patients. Oncology. 2012; 83: 24-30.
  82. Wu KJ, Yang MH. Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection. Biosci Rep2011;31: 449-55.
  83. Chang PM, Tzeng CH, Chen MH, Tsao CJ, Su WC, Hwang WS, Chang YF, Chang SY, Yang MH*. Triweekly reduced-dose docetaxel combined with cisplatin in recurrent/metastatic head and neck squamous cell carcinoma: a multicenter phase II study. Cancer Chemother Pharmacol. 2011;68:1477-1484..
  84. Hsieh YY, Mu-Hsin Chang P, Chen MH, Chu PY, Tzeng CH, Chang SY, Chen PM, Yang MH*. Pretreatment risk stratification for non-metastatic head and neck squamous cell carcinoma in a high-prevalence area. J Chin Med Assoc.2011;74:487-492.
  85. Tsai TL, Chu PY, Tai SK, Wang YF, Yang MH, Wang LW, Lirng JF, Chang SY*. Promising long-term results with attenuated adverse effects by methotrexate-containing sequential chemoradiation therapy in locally advanced head and neck squamous cell carcinoma.Jpn J Clin Oncol 2011; 41: 1182-1193.
  86. Wu MZ, Tsai YP, Yang MH, Huang CH, Chang SY, Chang CC, Teng SC, Wu KJ. Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition. Mol Cell2011; 43: 811-22.
  87. Pan JJ, Yang MH*. The role of epithelial-mesenchymal transition in pancreatic cancer. J Gastrointest Oncol 2011;2: 151-156.
  88. Hwang WL†, Yang MH†, Tsai ML, Lan HY, Su SH, Chang SC, Teng HW, Yang SH, Lan YT, Chiou SH, Wang HW. SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology. 2011; 141: 279-291, 291.e1-5. (†: equal contirbution).
  89. Huang YC, Chang PM, Chen MH, Chu PY, Tzeng CH, Chang SY, Yang MH*. A study using ifosfamide and etoposide in patients with cisplatin-refractory recurrent or metastatic head and neck squamous cell carcinoma. Jpn J Clin Oncol. 2011;41:630-636.
  90. Tai SK, Yang MH, Chang SY, Chang YC, Li WY, Tsai TL, Wang YF, Chu PY, Hsieh SL*. Persistent Krüppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma. Cancer Sci. 2011;102:895-902.
  91. Wu KJ, Yang MH. Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection. Biosci Rep 2011;31: 449-455 (review article).
  92. Lo T, Ho JH, Yang MH, Lee OK*. Glucose reduction prevents replicative senescence and increases mitochondrial respiration in human mesenchymal stem cells. Cell Transplant. 2011;20:813-825.
  93. Yang DC, Yang MH, Tsai CC, Huang TF, Chen YH, Hung SC. Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST. PLoS One. 2011;6:e23965.
  94. Chen YJ, Li HY, Huang CH, Twu NF, Yen MS, Wang PH, Chou TY, Liu YN, Chao KC, Yang MH*. Oestrogen-induced epithelial-mesenchymal transition of endometrial epithelial cells contributes to the development of adenomyosis. J Pathol. 2010; 222: 261-270.
  95. Yang MH*†, Hsu DS†, Wang HW, Wang HJ, Lan HY, Yang WH, Huang CH, Kao SY, Tzeng CH, Tai SK, Chang SY, Lee OK, Wu KJ*. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol 2010;12: 982-992. (†: equal contirbution)
  96. Chen MH, Chang PM, Chen PM, Tzeng CH, Chu PY, Chang SY, Yang MH*. Prolonged facial edema is an indicator of poor prognosis in patients with head and neck squamous cell carcinoma. Support Care Cancer 2010;18:1313-1319.
  97. Yang JM, Hung CM, Fu CN, Lee JC, Huang CH, Yang MH, Lin CL, Kao JY, Way TD. Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation.J Agric Food Chem2010; 58: 10020-10026.
  98. Hsu DS, Lan HY, Huang CH, Tai SK, Chang SY, Tsai TL, Chang CC, Tzeng CH, Wu KJ, Kao JY*, Yang MH*. Regulation of excision repair cross-complementation group 1 by Snail contributes to cisplatin resistance in head and neck cancer. Clin Cancer Res. 2010;16:4561-4571.
  99. Huang YC, Chang PM, Lee IC, Yang CF, Tzeng CH, Yang MH*. Duodenal squamous cell carcinoma derived from the hypopharynx: immunohistochemical assessment of metastatic mechanisms. Gastrointest Endosc2010; 72: 460-463.
  100. Chen YW, Yang MH, Kao SY, Wu CH. A rare complication of acquired factor VIII inhibitors in a postoperative oral cancer patient: a case report. J Oral Maxillofac Surg2010;68: 1989-1993.
  101. Chang PM, Hsieh YY, Chen MH, Tzeng CH, Chu PY, Chang SY, Chen PM, Yang MH*. Cetuximab-based therapy in recurrent/metastatic head and neck squamous cell carcinoma: experience from an area in which betel nut chewing is popular. J Chin Med Assoc 2010;73:292-299.
  102. Huang CH, Chen PM, Lu TC, Kung WM, Chiou TJ, Yang MH, Kao JY, Wu KJ. Purified recombinant TAT-homeobox B4 expands CD34(+) umbilical cord blood and peripheral blood progenitor cells ex vivo. Tissue Eng Part C Methods2010; 16: 487-496.
  103. Hsu DS, Chang SY, Liu CJ, Tzeng CH, Wu KJ, Kao JY*, Yang MH*. Identification of increased NBS1 expression as a prognostic marker of squamous cell carcinoma of the oral cavity. Cancer Sci2010;101:1029-37.
  104. Yang MH, Chang PM, Tzeng CH, Chang SY, Chu PY, Tai SK, Tsai TL, Wang YF, Huang JL, Wang HM*, Chen PM*. Promising overall survival of patients with recurrent/metastatic squamous cell carcinoma of head and neck receiving gemcitabine plus cisplatin treatment: report of a multi-center phase II study. Cancer Chemother Pharmacol. 2010;65: 259-265.
  105. Hsieh YY, Yang MH*. Deep into the cancer metastasis and development: TWIST activation by hypoxia-inducible factor-1. J Chinese Oncol Soc 2009; 25:317-325.
  106. Chen MH, Chang PM, Chen PM, Tzeng CH, Chu PY, Chang SY, Yang MH*. Prognostic significance of a pretreatment hematologic profile in patients with head and neck cancer.J Cancer Res Clin Oncol.2009;135:1783-1790.
  107. Huang CH, Yang WH, Chang SY, Tai SK, Tzeng CH, Kao JY, Wu KJ*, Yang MH*. Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis. Neoplasia. 2009;11: 1371-1382.
  108. Hung JJ, Yang MH, Hsu HS, Hsu WH, Liu JS, Wu KJ. Prognostic significance of hypoxia-inducible factor-1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer. Thorax. 2009; 64:1082-1089.
  109. Yang MH, Chen CL, Chau GY, Chiou SH, Su CW, Chou TY, Peng WL, Wu JC. Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology. 2009; 50: 1464-1474.
  110. Tsai YP, Yang MH, Huang CH, Chang SY, Chen PM, Liu CJ, Teng SC, Wu KJ*. Interaction between HSP60 and beta-catenin promotes metastasis. Carcinogenesis. 2009; 30: 1049-1057.
  111. Liu CY, Huang LJ, Wang WS, Chen TL, Yen CC, Yang MH, Hsiao LT, Liu CY, Chen PM, Chiou TJ*. Candidemia in cancer patients: impact of early removal of non-tunneled central venous catheters on outcome. J Infect2009; 58: 154-160.
  112. Chang PM, Chen PM, Chu PY, Wang LW, Tai SK, Tsai TL, Huang JL, Wang YF, Chang SY*, Yang MH*. Effectiveness of pharmacokinetic modulating chemotherapy combined with cisplatin as induction chemotherapy in resectable locally advanced head and neck cancer: phase II study. Cancer Chemother Pharmacol. 2008;63:9-17.
  113. Chang PM, Chen PM, Hsieh SL, Tzeng CH, Liu JH, Chiou TJ, Wang WS, Yen CC, Gau JP, Yang MH*. Expression of a soluble decoy receptor 3 in patients with diffuse large B-cell lymphoma predicts clinical outcome. Int J Oncol2008;33:549-54.
  114. Tai SK, Yang MH, Wang LW, Tsai TL, Chu PY, Wang YF, Huang JL, Chang SY*. Chemoradiotherapy laryngeal preservation for advanced hypopharyngeal cancer. Jpn J Clin Oncol2008; 38: 521-527.
  115. Yang MH, Wu KJ*. TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development. Cell Cycle2008; 7: 2090-2096.
  116. Chang PM, Teng HW, Chen PM, Chang SY, Chu PY, Tsai TL, Tai SK, Wang YF, Huang JL, Yang MH*. Methotrexate and leucovorin double-modulated 5-fluorouracil combined with cisplatin (MPFL) in metastatic/recurrent head and neck cancer. J Chin Med Assoc2008; 71: 336-341.
  117. Chen PM, Yen CC, Wang WS, Lin YJ, Chu CJ, Chiou TJ, Liu JH, Yang MH*. Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia. Int J Oncol 2008; 32: 1335-1341.
  118. Lee MY, Chiou TJ, Hsiao LT, Yang MH, Lin PC, Poh SB, Yen CC, Liu JH, Teng HW, Chao TC, Wang WS, Chen PM. Rituximab therapy increased post-transplant cytomegalovirus complications in Non-Hodgkin's lymphoma patients receiving autologous hematopoietic stem cell transplantation. Ann Hematol 2008; 87: 285-289.
  119. Chen YC, Chiang HY, Yang MH, Chen PM, Chang SY, Teng SC, Vanhaesebroeck B, Wu KJ*. Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif. J Mol Med (Berl). 2008; 86: 401-12.
  120. Chu Z, Chen JS, Liau CT, Wang HM, Lin YC, Yang MH, Chen PM, Gardner ER, Figg WD, Sparreboom A. Oral bioavailability of a novel paclitaxel formulation (Genetaxyl) administered with cyclosporin A in cancer patients. Anticancer Drugs. 2008; 19: 275-281.
  121. Yang MH†, Wu MZ†, Chiou SH, Chen PM, Chang SY, Liu CJ, Teng SC, Wu KJ*. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 2008; 10: 295-305. (†:equal contribution)
  122. Lin SC, Kau HC, Yang CF, Yang MH, Tsai CC, Kao SC, Hsu WM. Adenoid cystic carcinoma arising in the inferior orbit without evidence of lacrimal gland involvement. Ophthal Plast Reconstr Surg 2008; 24: 74-6.
  123. Yang MH, Chang SY, Chiou SH, Liu CJ, Chi CW, Chen PM, Teng SC, Wu KJ. Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer. Oncogene 2007; 26:1459-1467.
  124. Lin HL†, Yang MH†, Wu CW, Chen PM, Yang YP, Chu YR, Kao CL, Ku HH, Lo JF, Liou JP, Chi CW, Chiou SH. 2-methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer. Int J Cancer 2007; 121: 2547-55 (†: equal contirbution).
  125. Lee MY, Yang MH, Liu JH, Yen CC, Lin PC, Teng HW, Wang WS, Chiou TJ, Chen PM. Severe anaphylactic reactions in patients receiving oxaliplatin therapy: a rare but potentially fatal complication. Support Care Cancer 2007; 15:89-93.
  126. Yang MH, Chiang WC, Chou TY, Chang SY, Chen PM, Teng SC, Wu KJ. Increased NBS1 expression is a marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformation. Clin Cancer Res 2006; 12: 507-515.
  127. Hsiao LT, Chiou TJ, Liu JH, Chu CJ, Lin YC, Chao TC, Wang WS, Yen CC, Yang MH, Tseng CH, Chen PM. Extended lamivudine therapy against hepatitis B virus infection in hematopoietic stem cell transplant recipients. Biol Blood Marrow Transplant 2006;12: 84-94.
  128. Chen PM, Yen CC, Yang MH, Poh SB, Hsiao LT, Wang WS, Lin PC, Lee MY, Teng HW, Bai LY, Chu CJ, Chao SC, Yang AH, Chiou TJ, Liu JH, Chao TC. High prevalence of SV40 infection in patients with nodal non-Hodgkin's lymphoma but not acute leukemia independent of contaminated polio vaccines in Taiwan. Cancer Invest 2006; 24: 223-228.
  129. Lin PC, Lee MY, Wang WS, Yen CC, Chao TC, Hsiao LT, Yang MH, Chen PM, Lin KP, Chiou TJ. N-acetylcysteine has neuroprotective effects against oxaliplatin-based adjuvant chemotherapy in colon cancer patients: preliminary data. Support Care Cancer 2006;14: 484-487.
  130. Lin PC, Wang WS, Yang MH, Yen CC, Chao TC, Hsaio LT, Chen PM. Sequential therapy with capecitabine followed by vinorelbine/cisplatin in patients with anthracycline/taxane-refractory metastatic breast cancer. J Chin Med Assoc 2006;69:304-309.
  131. Yang MH, Yen CC, Chiang SC, Bai LY, Lee KD, Hsiao LT, Chao TC, Wang WS, Liu JH, Chiou TJ, Chen PM. Prognostic significance of clonal diversity of immunoglobulin gene rearrangements in patients with diffuse large B-cell lymphoma . Oncol Rep 2005 13: 503-508.
  132. Lin JT, Wang WS, Yen CC, Liu JH, Yang MH, Chao TC, Chen PM, Chiou TJ. Outcome of colorectal carcinoma in patients under 40 years of age. J Gastroenterol Hepatol 2005; 20:900-905.
  133. Chao TC, Chu Z, Tseng LM, Chiou TJ, Hsieh RK, Wang WS, Yen CC, Yang MH, Hsiao LT, Liu JH, Chen PM. Paclitaxel in a novel formulation containing less Cremophor EL as first-line therapy for advanced breast cancer: a phase II trial. Invest New Drugs 2005; 23:171-177.
  134. Lee MY, Chiou TJ, Yang MH, Bai LY, Hsiao LT, Chao TC, Tung SL, Wang WS, Yen CC, Liu JH, Chen PM. Relatively favorable outcomes of post-transplant pulmonary function in patients with chronic myeloid leukemia receiving non-myeloablative allogeneic hematopoietic stem cell transplantation. Eur J Haematol 2005; 74:152-157.
  135. Peng KL, Chen SJ, Lin PY, Hsu WM, Yang MH, Tzeng CH, Chen PM. Exudative bullous retinal detachment after peripheral blood stem cell transplantation. Eye 2005;19: 603-606.
  136. Liu JH, Yen CC, Lin YC, Gau JP, Yang MH, Chao TC, Hsiao LT, Wang WS, Tsai YC, Chen PM. Overexpression of cyclin D1 in accelerated-phase chronic myeloid leukemia. Leuk Lymphoma 2004; 45: 2419-2425.
  137. Chen PM, Yang MH, Hsiao LT, Yu IT, Chu CJ, Chao TC, Yen CC, Wang WS, Chiou TJ, Liu JH. Decreased FHIT protein expression correlates with a worse prognosis in patients with diffuse large B-cell lymphoma. Oncol Rep 2004; 11: 349-356.
  138. You JY, Chi KH, Yang MH, Chen CC, Ho CH, Chau WK, Hsu HC, Gau JP, Liu JH, Chen PM, Chiou TJ. Radiation therapy versus chemotherapy as initial treatment for localized nasal natural killer (NK)/T-cell lymphoma: a single institute survey in Taiwan. Ann Oncol 2004 ;15:618-625.
  139. Bai LY, Chiou TJ, Liu JH, Yen CC, Wang WS, Yang MH, Hsiao LT, Chao TC, Chen PM. Hematopoietic stem cell transplantation for severe aplastic anemia-experience of an institute in Taiwan. Ann Hematol 2004; 83:38-43.
  140. Liu JH, Wu SC, Chen WS, Yen CC, Yang MH, Tsai YC, Chen PM. An intron promotes the anti-bcr-abl activities of a retrovirally expressed ribozyme in chronic myeloid leukemia cells. Biochem Biophys Res Commun 2004; 318:764-772.
  141. Lin JT, Lee MY, Hsiao LT, Yang MH, Chao TC, Chen PM, Chiou TJ. Pulmonary nocardiosis in a patient with CML relapse undergoing imatinib therapy after bone marrow transplantation. Ann Hematol 2004; 83:444-446.
  142. Bai LY, Yang MH, Chiou TJ, Liu JH, Yen CC, Wang WS, Hsiao LT, Chao TC, Chen PM. Non-Hodgkin lymphoma in elderly patients: experience at Taipei Veterans General Hospital. Cancer 2003; 98:1188-1195.
  143. Lin JT, Wu MS, Wang WS, Yen CC, Chiou TJ, Liu JH, Yang MH, Chao TC, Chou SC, Chen PM. All-trans retinoid acid increases Notch1 transcript expression in acute promyelocytic leukemia. Adv Ther 2003; 20:337-343.
  144. Lin JT, Wang WS, Yen CC, Liu JH, Chiou TJ, Yang MH, Chao TC, Chen PM. Chryseobacterium indologenes bacteremia in a bone marrow transplant recipient with chronic graft-versus-host disease. Scand J Infect Dis 2003; 35:882-883.
  145. Yen CC, Chen YJ, Lu KS, Hsia JY, Chen JT, Hu CP, Chen PM, Liu JH, Chiou TJ, Wang WS, Yang MH, Chao TC, Lin CH. Genotypic analysis of esophageal squamous cell carcinoma by molecular cytogenetics and real-time quantitative polymerase chain reaction. Int J Oncol 2003 ; 23:871-881.
  146. Yang MH, Chiou TJ, Chao TC, Hsiao LT, Chen PM. Delayed rejection after initial engraftment in non-myeloablative bone marrow transplantation. J Chin Med Assoc 2003;66: 682-688 .
  147. Yang MH,Yen CC, Chen PM, Wang WS, Chang YH, Huang WJS, Fan FS, Chiou TJ, Liu JH, Chen KK. A prognostic-factors-based risk-stratification model for invasive urothelial carcinoma of the urinary bladder in Taiwan. Urology 2002; 59:232-238.
  148. Yang MH, Chen KK, Yen CC, Wang, WS, Chang YH, Huang WJS, Fan FS, Chiou TJ, Liu JH, Chen PM. Unusual high incidence of upper-urinary-tract urothelial carcinoma in Taiwan. Urology 2002; 59:681-687.
  149. Chen PM, Yang MH, Yu IT, Lin JT, Lin YC, Fan FS, Wang WS, Yen CC, Chiou TJ, Liu JH. Low incidence of BCL-6 gene alterations for diffuse large B cell lymphomas in Taiwan Chinese. Cancer 2002; 94:2635-2644.
  150. Chen PM, Yao NS, Wu CM, Yang MH, Lin YC, Hsiao LT, Yen CC, Wang WS, Fan FS, Chiou TJ, Liu JH, Lo SJ. Detection of reactivation and genetic mutations of the hepatitis B virus in patients with chronic hepatitis B infections receiving hematopoietic stem cell transplantation. Transplantation 2002; 74:282-288.
  151. Lin JT, Wang WS, Yen CC, Chiou TJ, Liu JH, Hsiao LT, Yang MH, Chao TC, Tai CJ, Chen PM. Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: remission of refractory anemia following mycophenolate mofetil. Ann Hematol 2002 ; 81:723-726.
  152. · Lin JT, Wang WS, Yen CC, Chiou TJ, Liu JH, Hsiao LT, Yang MH, Chao TC, Tai CJ, Chen PM. Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: remission of refractory anemia following mycophenolate mofetil. Ann Hematol 2002; 81:723-726.
  153. Chen YC, Chiou TJ, Yang MH, Yu IT. Two easy-to-perform diagnostic tests for Gilbert's syndrome. J Chin Med Assoc 2002;65:231-234.
  154. Yang MH, Hsu HC. Pure red cell aplasia after ABO-incompatible allogeneic stem cell transplantation in severe aplastic anemia with response to steroids: a case report and literature review. Ann Hematol 2001; 80:299-301.
  155. Liu JH, Yang MH, Fan FS, Yen CC, Wang WS, Chang YH, Chen KK, Chen PM. Tamoxifen and colchicine-modulated vinblastine followed by 5-fluorouracil in advanced renal cell carcinoma : a phase II study. Urology 2001; 57: 650-654.
  156. Chen PM, Chiou TJ, Yu IT, Fan FS, Chu CJ, Kao SC, Wang WS, Liu JH, Hsu WM, Yang MH, Chao TC, Tai CJ, Hsiao LT, Lin JT, Yen CC. Molecular analysis of mucosa-associated lymphoid tissue (MALT) lymphoma of ocular adnexa. Leukemia Lymphoma 2001; 42:207-214.
  157. Hung GY, Chiou TJ, Hsieh YL, Yang MH, Chen WYK. Intestinal metastasis causing intussusception in a patient treated for osteosarcoma with history of multiple metastases: a case report. Jpn J Clin Oncol 2001; 31: 165-167.
  158. Yang MH, Ho CH. 2-Chlorodeoxyadenosine (Cladribine) in the treatment of hairy cell leukemia. J Chin Med Assoc 2001;64: 54-58.
  159. Yang MH, Yen CC, Chang YH, Hsieh RK, Liu JH, Chiou TJ, Fan FS, Lin ATL, Huang WJS, Wang WS, Chen KK, Chen PM. Single agent paclitaxel as a first-line therapy in advanced urothelial carcinoma : its efficacy and safety in patients even with pretreatment renal insufficiency. Jpn J Clin Oncol 2000; 30: 547-552.
  160. Yang MH, Fan FS, Chen PM, Liu JH, Chiou TJ, Wang WS, Yen CC. Venous gangrene in a patient with adenocarcinoma of lung. Jpn J Clin Oncol 2000; 30: 276-278. Yen CC, Liu JH, Wang WS, Fan FS, Chiou TJ, Tai CJ,
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